CLOSTRIDIOIDES DIFFICILE TOXIN B SUBVERTS GERMINAL CENTER AND ANTIBODY RECALL RESPONSES BY STIMULATING A DRUG-TREATABLE CXCR4-DEPENDENT MECHANISM

Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism

Summary: Recurrent Clostridioides difficile infection (CDI) results in significant morbidity and mortality.We previously established that CDI in mice does not protect against reinfection and is associated with poor pathogen-specific B cell memory (Bmem), recapitulating our observations with human Bmem.Here, we demonstrate that the secreted toxin Tc

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Effect of ingestion of saline, glucose, and ethanol on mobilization and hepatic incorporation of epididymal pad palmitate-1-14C in rats

The effect plastic molcajete bowls of ingestion of saline, glucose, and ethanol (isocaloric with the glucose) on the mobilization of radiopalmitate from epididymal fat prelabeled in vivo and the incorporation of the mobilized label into liver lipids was investigated in rats.The mobilization of radiopalmitate from epididymal fat and the incorporatio

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